Okami, at first I thought it was Okage: Shadow king. LOL Was that game ever, interesting.... I loved it, but there was way to much talking. And I was to young to even understand what was happening. The monsters you had to fight were always the same, either random flowers, like treasure chests... It was really weird. As for Okami, I don't think i've ever heard of it.
Coming in 9th place: Metal gear solid: subsistence(the third)
8th: TimeSplitters

, that game was definitely unique. Running around with headless cows, killing eachother.
7th: Even with it's childish theme & graphics i'm going to have to say Ratchet and Clank, the second and up your Arsenal. They were both equally good. And just fun to play.
6th: Final Fantasy XII: I loved the game, but people made me hate it. Constant criticizing can do that, the battle system was amazing to me, and I would just set on the uh... What do you call them. Gambits? I would rig them so while I was at school, my party was able to train and train. It was crazy.
5th: Metal gear solid: Sons of liberty, it was much better than the 3rd one, in my opinion.
4th: God of war
3rd: All Soul Calibur Games, I loved being able to choose from familiar characters.
2nd: Resident evil 4
And coming in 1st, BOOOMBBEERRR MAAAANNN,

Nah. But seriously, I really don't know what the best game is, and by the way those rankings aren't really accurate,
I was just thinking of my favorite games, so technically the games are accurate just not the positions, however they're close enough. I'll think of a number one game soon, but for now I'm going to have to say
Okage: Shadow king.