Suru.

[Eliytres]

can you use it with "you are making me sick"?

[Daichi]

I'm not sure, but in any case that is a rather rude thing to say, and probably wouldn't be appreciated by any Japanese person, regardless of how fluently you said it!

[Harisenbon]

I really don't understand your question. する　 is the plain form of the verb to do. To turn it into causitive (make N do something) you would use させる. However, the phrase you make me sick actually translates into something more akin to:

気持ち悪い
or
胸糞が悪くなる

[Eliytres]

the question is: can i make "suru" to act like the english verb "make"?

[Harisenbon]

Yes, but not in the example you posted.

いadj く+ する or なadj + にする will give you the meaning "make"

難しくする - make it harder
簡単にする - make it easy
赤くする - make it red

[Eliytres]

arigatou!